Full Name: Sphingosine-1-Phosphate Receptor 1
BACKGROUND: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants.
Synonyms: CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1
Research Areas: Cell Biology
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