Full Name: Lysine Demethylase 4A
BACKGROUND: This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
Synonyms: JHDM3A; JMJD2; JMJD2A; TDRD14A
Research Areas: Epigenetics
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