Full Name: Interleukin 1 Receptor Associated Kinase 3
BACKGROUND: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
Synonyms: ASRT5; IRAKM
Research Areas: Signal Transduction
Pathways: Signal Transduction Pathway
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