Full Name: Farnesyl-Diphosphate Farnesyltransferase 1
BACKGROUND: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
Synonyms: DGPT; ERG9; SQS; SS
Research Areas: Cardiovascular Biology
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