Full Name: N-Acylsphingosine Amidohydrolase 2
BACKGROUND: Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001[PubMed 11328816]).
Synonyms: BCDase; HNAC1; LCDase; N-CDase; NCDase
Research Areas: Cardiovascular Biology
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