Full Name: Arachidonate 15-Lipoxygenase, Type B
BACKGROUND: This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms: Arachidonate 15-Lipoxygenase, Type B; Arachidonate 15-Lipoxygenase, Second Type; Arachidonate 15-Lipoxygenase Type II; Linoleate 13-Lipoxygenase 15-LOb; EC 1.13.11.33; 15-LOX-2
Research Areas: Metabolism
Pathways: Metabolism Pathway
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