Anti-WNT10B Monoclonal Antibody (C-13F4)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C1974	Anti-WNT10B Antibody (C-13F4)	Mouse IgG		None		$460		Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASZ1C1974

Anti-WNT10B Antibody (C-13F4)

Mouse IgG

None

$460

Add

Anti-WNT10B Monoclonal Antibody (C-13F4)
- Product Description:
  
  The Anti-WNT10B antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human WNT10B.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  WNT10B
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Wnt Family Member 10B (WNT10B).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  C-13F4
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.02% sodium azide
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-WNT10B Monoclonal Antibody (C-13F4) Applications
- Recommended Dilution:
  
  Western Blot: 1:500-1:5000
  Immunohistochemistry: 1:50-1:200
  Immunocytochemistry: 1:50-1:200
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

Protein Wnt-10b

Introduction

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.

Alternative Names

SHFM6; STHAG8; WNT-12

Gene ID

7480

UniProt

O00744

Related Disease

Split-hand/foot malformation 6 (SHFM6)

Subcellular Location

Secreted, extracellular space, extracellular matrix

Tissue Specificity

Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.

Cell Line Specificity

Cancer enhanced

Function

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.

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