Anti-VWF Monoclonal Antibody (82D6A3)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC152	Anti-VWF Antibody (82D6A3)	Mouse IgG2a, Kappa		None	$460	In stock	Add
ASPC152-P	Anti-VWF Antibody (82D6A3), PE	Mouse IgG2a, Kappa		PE	$1,180	2-3 weeks	Add
ASPC152-A	Anti-VWF Antibody (82D6A3), APC	Mouse IgG2a, Kappa		APC	$980	2-3 weeks	Add
ASPC152-H	Anti-VWF Antibody (82D6A3), HRP	Mouse IgG2a, Kappa		HRP	$600	2-3 weeks	Add
ASPC152-B	Anti-VWF Antibody (82D6A3), Biotin	Mouse IgG2a, Kappa		Biotin	$680	2-3 weeks	Add
ASPC152-4	Anti-VWF Antibody (82D6A3), Fc Silenced	Mouse IgG1, Kappa	Fc Silenced	None	$980	4-6 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC152

Anti-VWF Antibody (82D6A3)

Mouse IgG2a, Kappa

None

$460

In stock

Add

ASPC152-P

Anti-VWF Antibody (82D6A3), PE

Mouse IgG2a, Kappa

$1,180

2-3 weeks

Add

ASPC152-A

Anti-VWF Antibody (82D6A3), APC

Mouse IgG2a, Kappa

APC

$980

2-3 weeks

Add

ASPC152-H

Anti-VWF Antibody (82D6A3), HRP

Mouse IgG2a, Kappa

HRP

$600

2-3 weeks

Add

ASPC152-B

Anti-VWF Antibody (82D6A3), Biotin

Mouse IgG2a, Kappa

Biotin

$680

2-3 weeks

Add

ASPC152-4

Anti-VWF Antibody (82D6A3), Fc Silenced

Mouse IgG1, Kappa

Fc Silenced

None

$980

4-6 weeks

Add

Anti-VWF Monoclonal Antibody (82D6A3)
- Product Description:
  
  82D6A3 is a monoclonal antibody that specifically targets the A3 domain of human von Willebrand Factor (vWF). vWF is composed of several distinct domains (D1-D4, A1-A3, C1-C2, and others), each contributing to its functions. The A3 domain is specifically involved in binding to collagen within the subendothelial matrix, which is essential for platelet adhesion during the initial stages of blood clot formation.
  
  Applications:
  
  Inhibition, Enzyme-Linked Immunosorbent Assay, Surface Plasmon Resonance
  
  Source:
  
  Mouse
  
  Target:
  
  VWF
  
  Target Species:
  
  Human
  
  Specificity:
  
  The A3 domain of human von Willebrand Factor (vWF)
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  82D6A3
  
  Isotype:
  
  Mouse IgG2a, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-VWF Monoclonal Antibody (82D6A3) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

VWF

Protein Name

von Willebrand factor

Introduction

This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22.

Alternative Names

Von Willebrand Factor; F8VWF; Coagulation Factor VIII VWF; VWD; VWF

Gene ID

7450

UniProt

P04275

Related Disease

von Willebrand disease 1 (VWD1)

Tissue Specificity

Plasma.

Cell Type

Platelets

Function

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

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