Anti-VEGFA Monoclonal Antibody (Bevacizumab)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC035	Anti-VEGFA Antibody (Bevacizumab)	Human IgG1, Kappa		None	$460	In stock	Add
ASPC035-P	Anti-VEGFA Antibody (Bevacizumab), PE	Human IgG1, Kappa		PE	$1,180	2-3 weeks	Add
ASPC035-A	Anti-VEGFA Antibody (Bevacizumab), APC	Human IgG1, Kappa		APC	$980	2-3 weeks	Add
ASPC035-H	Anti-VEGFA Antibody (Bevacizumab), HRP	Human IgG1, Kappa		HRP	$600	2-3 weeks	Add
ASPC035-B	Anti-VEGFA Antibody (Bevacizumab), Biotin	Human IgG1, Kappa		Biotin	$680	2-3 weeks	Add
ASPC035-4	Anti-VEGFA Antibody (Bevacizumab), Fc Silenced	Human IgG1, Kappa	Fc Silenced	None	$980	4-6 weeks	Add

Anti-VEGFA Monoclonal Antibody (Bevacizumab)
- Product Description:
  
  Bevacizumab is designed to inhibit VEGF-A, a key regulator in angiogenesis (formation of new blood vessels). By binding to VEGF-A, Bevacizumab prevents it from interacting with its receptors (VEGFR-1 and VEGFR-2) on the surface of endothelial cells.
  
  Applications:
  
  Immunoprecipitation, Western Blot, Blocking, Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Target:
  
  VEGFA
  
  Target Species:
  
  Human
  
  Specificity:
  
  Native and reduced human VEGF165
  
  Immunogen:
  
  Human VEGF protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  Bevacizumab
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-VEGFA Monoclonal Antibody (Bevacizumab) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

VEGFA

Protein Name

Vascular endothelial growth factor A, long form

Molecular Family

Cytokines/Chemokines

Introduction

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.

Alternative Names

Vascular Endothelial Growth Factor A; Vascular Permeability Factor; VEGF; VPF; Vascular Endothelial Growth Factor A121; Vascular Endothelial Growth Factor A165; Vascular Endothelial Growth Factor; VEGF-A; MVCD1

Gene ID

7422

UniProt

P15692

Related Disease

Microvascular complications of diabetes 1 (MVCD1)

Tissue Specificity

Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.

Cell Type

Epithelial cells

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