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Anti-UBE2I Monoclonal Antibody (SAIC-36A-9)
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Product Description:The Anti-UBE2I antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, western blot and other applications. This antibody specifically targets UBE2I and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western BlotTarget:UBE2ITarget Species:HumanSpecificity:This antibody reacts with Human UBE2I.Immunogen:PeptideClonality:MonoclonalClone ID:SAIC-36A-9Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-UBE2I Monoclonal Antibody (SAIC-36A-9) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
UBE2I
Protein Name
SUMO-conjugating enzyme UBC9
Introduction
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alternative Names
C358B7.1; P18; UBC9
Gene ID
UniProt
Subcellular Location
Nucleus
Tissue Specificity
Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.
Cell Line Specificity
Low cancer specificity
Function
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705).
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