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Anti-UBE2C Monoclonal Antibody (SAIC-41C-6)
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Product Description:The Anti-UBE2C antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, western blot and other applications. This antibody specifically targets UBE2C and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western blotTarget:UBE2CTarget Species:HumanSpecificity:This antibody reacts with Human UBE2C.Immunogen:PeptideClonality:MonoclonalClone ID:SAIC-41C-6Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-UBE2C Monoclonal Antibody (SAIC-41C-6) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
UBE2C
Protein Name
Ubiquitin-conjugating enzyme E2 C
Introduction
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19.
Alternative Names
UBCH10; dJ447F3.2
Gene ID
UniProt
Cell Line Specificity
Low cancer specificity
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
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