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Anti-TRAC Monoclonal Antibody (34)
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Product Description:This product is a mouse monoclonal antibody (clone 34) that recognizes the constant region of human T-cell receptor α chain (TRAC), is validated in Western blot, ELISA and flow cytometry, is azide-free, and enables quantification of TCR-engineered cells in adoptive-therapy protocols.Applications:Western Blot, Enzyme-linked Immunosorbent Assay, Flow CytometrySource:MouseTarget:TRACTarget Species:HumanSpecificity:This antibody reacts with Human TRAC.Immunogen:Purified recombinant soluble TCR from the T-cell hybridoma 85.33, corresponding to V alpha 11Clonality:MonoclonalClone ID:34Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-TRAC Monoclonal Antibody (34) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
TRAC
Protein Name
T Cell Receptor Alpha Constant
Introduction
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. The T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes.
Alternative Names
T Cell Receptor Alpha Constant; TCRA; T-Cell Receptor Alpha Constant; IMD7; TRCA; TRA
Gene ID
UniProt
Subcellular Location
Cell membrane
Tissue Specificity
Tissue enriched (Lymphoid tissue)
Cell Line Specificity
Group enriched (Leukemia, Lymphoma)
Function
The alpha constant region of the T cell receptor.
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