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Anti-TNFSF13B Monoclonal Antibody (Tabalumab)
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Product Description:Tabalumab is a fully human monoclonal antibody that targets and neutralizes BAFF. BAFF is a critical cytokine for B cell development, survival, and activation.Applications:Functional Assay, Immunoprecipitation, Neutralization, Enzyme-Linked Immunosorbent Assay, Western Blot, Flow Cytometry, ImmunofluorescenceSource:HumanTarget:TNFSF13BSpecificity:Human BAFFImmunogen:Human TNFSF13B proteinClonality:MonoclonalClone ID:TabalumabIsotype:Human IgG4-S228P, KappaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-TNFSF13B Monoclonal Antibody (Tabalumab) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
TNFSF13B
Protein Name
Tumor necrosis factor ligand superfamily member 13B
Molecular Family
CD Molecules, Cytokines/Chemokines, Growth Factors, Soluble Receptors
Introduction
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Alternative Names
TNF Superfamily Member 13b; Tumor Necrosis Factor (Ligand) Superfamily, Member 13b; Dendritic Cell-Derived TNF-Like Molecule; B-Cell-Activating Factor; TNFSF20; TALL-1; TALL1; ZTNF4; BAFF; BLYS; Tumor Necrosis Factor (Ligand) Superfamily, Member 20; Tumor Necrosis Factor Ligand Superfamily Member 13B; TNF- And APOL-Related Leukocyte Expressed Ligand 1; TNF And ApoL-Related Leukocyte Expressed Ligand 1; Tumor Necrosis Factor Superfamily Member 13b
Gene ID
UniProt
Subcellular Location
Vesicles,Plasma membrane,Focal adhesion sites
Tissue Specificity
Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines.
Cell Type
B cells, Dendritic cells, Eosinophils, Mast cells, Monocytes, NK cells, T cells, Thymocytes, Tregs
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