Anti-TNFSF13B Monoclonal Antibody

Subcat	Description	Isotype	Conjugate	Price
ASPC1392	Anti-TNFSF13B Antibody	Mouse IgG1, Kappa	None	$460	Add
ASPC1392-A	Anti-TNFSF13B Antibody, APC	Mouse IgG1, Kappa	APC	$980	Add
ASPC1392-B	Anti-TNFSF13B Antibody, Biotin	Mouse IgG1, Kappa	Biotin	$680	Add
ASPC1392-H	Anti-TNFSF13B Antibody, HRP	Mouse IgG1, Kappa	HRP	$600	Add
ASPC1392-P	Anti-TNFSF13B Antibody, PE	Mouse IgG1, Kappa	PE	$1,180	Add

Anti-TNFSF13B Monoclonal Antibody
- Product Description:
  
  The Anti-TNFSF13B antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, blocking and other applications. This antibody specifically targets TNFSF13B and demonstrates reactivity with Human, Cynomolgus Monkey, Mouse.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Blocking
  
  Source:
  
  Mouse
  
  Target:
  
  TNFSF13B
  
  Specificity:
  
  This antibody reacts with TNFSF13B.
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-TNFSF13B Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

TNFSF13B

Protein Name

Tumor necrosis factor ligand superfamily member 13B

Introduction

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Alternative Names

TNF Superfamily Member 13b; Tumor Necrosis Factor (Ligand) Superfamily, Member 13b; Dendritic Cell-Derived TNF-Like Molecule; B-Cell-Activating Factor; TNFSF20; TALL-1; TALL1; ZTNF4; BAFF; BLYS; Tumor Necrosis Factor (Ligand) Superfamily, Member 20; Tumor Necrosis Factor Ligand Superfamily Member 13B; TNF- And APOL-Related Leukocyte Expressed Ligand 1; TNF And ApoL-Related Leukocyte Expressed Ligand 1; Tumor Necrosis Factor Superfamily Member 13b

Gene ID

10673

UniProt

Q9Y275

Tissue Specificity

Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines.

Cell Line Specificity

Cancer enriched

Function

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

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