Anti-TNFSF11 Monoclonal Antibody (2A4)

Subcat	Description	Isotype	Conjugate	Price
ASPC1391	Anti-TNFSF11 Antibody (2A4)	Mouse IgG2a, Kappa	None	$460	Add
ASPC1391-A	Anti-TNFSF11 Antibody (2A4), APC	Mouse IgG2a, Kappa	APC	$980	Add
ASPC1391-B	Anti-TNFSF11 Antibody (2A4), Biotin	Mouse IgG2a, Kappa	Biotin	$680	Add
ASPC1391-H	Anti-TNFSF11 Antibody (2A4), HRP	Mouse IgG2a, Kappa	HRP	$600	Add
ASPC1391-P	Anti-TNFSF11 Antibody (2A4), PE	Mouse IgG2a, Kappa	PE	$1,180	Add

Anti-TNFSF11 Monoclonal Antibody (2A4)
- Product Description:
  
  The Anti-TNFSF11 antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay and other applications. This antibody specifically targets TNFSF11 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  TNFSF11
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human TNFSF11.
  
  Immunogen:
  
  Human Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  2A4
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-TNFSF11 Monoclonal Antibody (2A4) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

TNFSF11

Protein Name

Tumor necrosis factor ligand superfamily member 11

Introduction

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative Names

CD254; ODF; OPGL; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2; sOdf

Gene ID

8600

UniProt

O14788

Subcellular Location

Isoform 1: Cell membrane; Single-pass type II membrane protein. Isoform 3: Cell membrane; Single-pass type II membrane protein. Isoform 2: Cytoplasm

Tissue Specificity

Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

Cell Line Specificity

Cancer enhanced

Function

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).

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