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Anti-TNFRSF9 Monoclonal Antibody (4B4-1-1)
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Product Description:The Anti-TNFRSF9 antibody is a mouse monoclonal antibody recommended for use in immunohistochemistry, flow cytometry, enzyme-linked immunosorbent assay, blocking and other applications. This antibody specifically targets TNFRSF9 and demonstrates reactivity with human.Applications:Immunohistochemistry, Flow Cytometry, Enzyme-Linked Immunosorbent Assay, BlockingTarget:TNFRSF9Target Species:HumanSpecificity:This antibody reacts with Human TNFRSF9.Immunogen:Human 4-1BB proteinClonality:MonoclonalClone ID:4B4-1-1Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-TNFRSF9 Monoclonal Antibody (4B4-1-1) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
TNFRSF9
Protein Name
Tumor necrosis factor receptor superfamily member 9
Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Alternative Names
4-1BB; CD137; CDw137; ILA
Gene ID
UniProt
Subcellular Location
Cell membrane
Tissue Specificity
Expressed on the surface of activated T-cells.
Cell Line Specificity
Low cancer specificity
Function
Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).
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