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Anti-TNFRSF25 Monoclonal Antibody (8G7)
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Product Description:The Anti-TNFRSF25 antibody is a mouse monoclonal antibody recommended for use in ELISA and other applications. This antibody specifically targets TNFRSF25 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent AssayTarget:TNFRSF25Target Species:HumanSpecificity:This antibody reacts with human DR3.Immunogen:Full length human TNFRSF25 proteinClonality:MonoclonalClone ID:8G7Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-TNFRSF25 Monoclonal Antibody (8G7) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
TNFRSF25
Protein Name
Tumor necrosis factor receptor superfamily member 25
Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Alternative Names
DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; GEF720; WSL-LR; PLEKHG5; TNFRSF12
Gene ID
UniProt
Molecule Mass
Cytokine/Chemokine Receptors
Tissue Specificity
Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Cell Line Specificity
Low cancer specificity
Function
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
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