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Anti-TNFRSF1A Monoclonal Antibody (1C4)
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Product Description:The Anti-TNFRSF1A antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry, neutralization and other applications. This antibody specifically targets TNFRSF1A and demonstrates reactivity with human, rhesus monkey.Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, NeutralizationTarget:TNFRSF1ATarget Species:HumanSpecificity:This antibody reacts with human TNFR1 (TNF Receptor 1).Clonality:MonoclonalClone ID:1C4Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-TNFRSF1A Monoclonal Antibody (1C4) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
TNFRSF1A
Protein Name
Tumor necrosis factor receptor superfamily member 1A
Introduction
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.
Alternative Names
FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55
Gene ID
UniProt
Molecule Mass
CD Molecules
Related Disease
Periodic fever, familial, autosomal dominant (FPF)
Subcellular Location
Cell membrane
Cell Line Specificity
Low cancer specificity
Function
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
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