Anti-TMEM30A Monoclonal Antibody (12H10)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC631	Anti-TMEM30A Antibody (12H10)	Mouse IgG1, Kappa	None	$460	In stock	Add
ASPC631-P	Anti-TMEM30A Antibody (12H10), PE	Mouse IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC631-A	Anti-TMEM30A Antibody (12H10), APC	Mouse IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC631-H	Anti-TMEM30A Antibody (12H10), HRP	Mouse IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC631-B	Anti-TMEM30A Antibody (12H10), Biotin	Mouse IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-TMEM30A Monoclonal Antibody (12H10)
- Product Description:
  
  The Anti-TMEM30A antibody is a mouse monoclonal antibody recommended for use in ELISA, flow cytometry and other applications. This antibody specifically targets TMEM30A and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Target:
  
  TMEM30A
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human TMEM30A.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  12H10
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-TMEM30A Monoclonal Antibody (12H10) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

TMEM30A

Protein Name

Cell cycle control protein 50A

Introduction

TMEM30A functions as the beta subunit for several P4 ATPases, playing a role in their catalytic reaction cycles and regulating their correct membrane localization.

Alternative Names

TMEM30A; transmembrane protein 30A; CDC50A; C6orf67; cell cycle control protein 50A; P4-ATPase flippase complex beta subunit TMEM30A

Gene ID

55754

UniProt

Q9NV96

Subcellular Location

Membrane

Cell Line Specificity

Low cancer specificity

Function

Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations.

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