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Anti-TLR9 Monoclonal Antibody (5B11)
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Product Description:The Anti-TLR9 antibody is a mouse monoclonal antibody recommended for use in ELISA, flow cytometry, immunohistochemistry and other applications. This antibody specifically targets TLR9 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, ImmunohistochemistryTarget:TLR9Target Species:HumanSpecificity:This antibody reacts with human TLR9C.Immunogen:Mouse Toll Like Receptor 9Clonality:MonoclonalClone ID:5B11Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-TLR9 Monoclonal Antibody (5B11) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
TLR9
Protein Name
Toll-like receptor 9
Introduction
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Alternative Names
CD289; Toll Like Receptor 9
Gene ID
UniProt
Molecule Mass
CD Molecules, Innate Immune Signaling, Toll Like Receptors
Subcellular Location
Endoplasmic reticulum membrane
Tissue Specificity
Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Cell Line Specificity
Cancer enhanced
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