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Anti-TIMP4 Monoclonal Antibody (D-1D11)
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Product Description:The Anti-TIMP4 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human TIMP4.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:TIMP4Target Species:HumanSpecificity:This antibody reacts with human TIMP Metallopeptidase Inhibitor 4 (TIMP4).Clonality:MonoclonalClone ID:D-1D11Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.02% sodium azideShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-TIMP4 Monoclonal Antibody (D-1D11) Applications
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Recommended Dilution:Western Blot: 1:500-1:5000
Immunohistochemistry: 1:50-1:200
Immunocytochemistry: 1:50-1:200Note:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Metalloproteinase inhibitor 4
Introduction
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
Alternative Names
TIMP Metallopeptidase Inhibitor 4; Tissue Inhibitor Of Metalloproteinases 4; Tissue Inhibitor Of Metalloproteinase 4; TIMP-4; Metalloproteinase Inhibitor 4
Gene ID
UniProt
Subcellular Location
Secreted.
Tissue Specificity
Abundant in heart and present at low levels in many other tissues.
Cell Line Specificity
Low cancer specificity
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
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