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Anti-TGFB1 Monoclonal Antibody (14H6)
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Product Description:The Anti-TGFB1 antibody is a human monoclonal antibody recommended for use in immunohistochemistry, neutralization, functional assay and other applications. This antibody specifically targets TGFB1 and demonstrates reactivity with human, rat and mouse.Applications:Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, Neutralization, Functional AssayTarget:TGFB1Specificity:This antibody reacts with human TGFB1.Clonality:MonoclonalClone ID:14H6Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-TGFB1 Monoclonal Antibody (14H6) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
TGFB1
Protein Name
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide
Introduction
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha.
Alternative Names
Transforming Growth Factor Beta 1; Prepro-Transforming Growth Factor Beta-1; TGF-Beta-1; TGFB; Transforming Growth Factor, Beta 1
Gene ID
UniProt
Molecule Mass
Cytokines/Chemokines, Growth Factors
Related Disease
Camurati-Engelmann disease (CAEND)
Subcellular Location
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix
Function
Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
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