Anti-SOST Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Conjugate	Price
ASPC1359	Anti-SOST Antibody	Human IgG1, Kappa	None	$460	Add
ASPC1359-A	Anti-SOST Antibody, APC	Human IgG1, Kappa	APC	$980	Add
ASPC1359-B	Anti-SOST Antibody, Biotin	Human IgG1, Kappa	Biotin	$680	Add
ASPC1359-H	Anti-SOST Antibody, HRP	Human IgG1, Kappa	HRP	$600	Add
ASPC1359-P	Anti-SOST Antibody, PE	Human IgG1, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1359

Anti-SOST Antibody

Human IgG1, Kappa

None

$460

Add

ASPC1359-A

Anti-SOST Antibody, APC

Human IgG1, Kappa

APC

$980

Add

ASPC1359-B

Anti-SOST Antibody, Biotin

Human IgG1, Kappa

Biotin

$680

Add

ASPC1359-H

Anti-SOST Antibody, HRP

Human IgG1, Kappa

HRP

$600

Add

ASPC1359-P

Anti-SOST Antibody, PE

Human IgG1, Kappa

$1,180

Add

Anti-SOST Monoclonal Antibody
- Product Description:
  
  The Anti-SOST antibody is a human monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, neutralization and other applications. This antibody specifically targets SOST and demonstrates reactivity with human and mouse.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Neutralization
  
  Target:
  
  SOST
  
  Target Species:
  
  Mouse
  
  Specificity:
  
  This antibody reacts with SOST.
  
  Immunogen:
  
  Mouse SOST protein
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-SOST Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

SOST

Protein Name

Sclerostin

Introduction

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Alternative Names

SOST; sclerostin; CDD; VBCH; DAND6; SOST1

Gene ID

50964

UniProt

Q9BQB4

Related Disease

Sclerosteosis 1 (SOST1)

Subcellular Location

Secreted, extracellular space, extracellular matrix

Tissue Specificity

Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).

Cell Line Specificity

Cancer enhanced

Function

Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

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