Anti-SNAP25 Monoclonal Antibody (12F8)

Subcat	Description	Isotype	Conjugate	Price
ASPC497	Anti-SNAP25 Antibody (12F8)	Human IgG1, Kappa	None	$460	Add
ASPC497-P	Anti-SNAP25 Antibody (12F8), PE	Human IgG1, Kappa	PE	$1,180	Add
ASPC497-A	Anti-SNAP25 Antibody (12F8), APC	Human IgG1, Kappa	APC	$980	Add
ASPC497-H	Anti-SNAP25 Antibody (12F8), HRP	Human IgG1, Kappa	HRP	$600	Add
ASPC497-B	Anti-SNAP25 Antibody (12F8), Biotin	Human IgG1, Kappa	Biotin	$680	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC497

Anti-SNAP25 Antibody (12F8)

Human IgG1, Kappa

None

$460

Add

ASPC497-P

Anti-SNAP25 Antibody (12F8), PE

Human IgG1, Kappa

$1,180

Add

ASPC497-A

Anti-SNAP25 Antibody (12F8), APC

Human IgG1, Kappa

APC

$980

Add

ASPC497-H

Anti-SNAP25 Antibody (12F8), HRP

Human IgG1, Kappa

HRP

$600

Add

ASPC497-B

Anti-SNAP25 Antibody (12F8), Biotin

Human IgG1, Kappa

Biotin

$680

Add

Anti-SNAP25 Monoclonal Antibody (12F8)
- Product Description:
  
  The Anti-SNAP25 antibody is a human monoclonal antibody recommended for use in ELISA, Immunocytochemistry, immunoprecipitation, immunofluorescence and other applications. This antibody specifically targets SNAP25 and demonstrates reactivity with human, rat.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Immunocytochemistry, Immunoprecipitation, Immunofluorescence, Western Blot
  
  Target:
  
  SNAP25
  
  Specificity:
  
  This antibody reacts with SNAP25.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  12F8
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-SNAP25 Monoclonal Antibody (12F8) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

SNAP25

Protein Name

Synaptosomal-associated protein 25

Introduction

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release.

Alternative Names

SUP; RIC4; SEC9; SNAP; CMS18; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2

Gene ID

6616

UniProt

P60880

Molecule Mass

Presynaptic proteins

Related Disease

Myasthenic syndrome, congenital, 18 (CMS18)

Subcellular Location

Cytoplasm, perinuclear region

Tissue Specificity

Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.

Cell Line Specificity

Cancer enhanced

Function

t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

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