Anti-SKIL Monoclonal Antibody (2B6)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C1671	Anti-SKIL Antibody (2B6)	Mouse IgG		None		$460		Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASZ1C1671

Anti-SKIL Antibody (2B6)

Mouse IgG

None

$460

Add

Anti-SKIL Monoclonal Antibody (2B6)
- Product Description:
  
  The Anti-SKIL antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human SKIL.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  SKIL
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human SKI Like Proto-Oncogene (SKIL).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  2B6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.02% sodium azide
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-SKIL Monoclonal Antibody (2B6) Applications
- Recommended Dilution:
  
  Western Blot: 1:500-1:5000
  Immunohistochemistry: 1:50-1:200
  Immunocytochemistry: 1:50-1:200
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

Ski-like protein

Introduction

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

Alternative Names

SNO; SnoA; SnoI; SnoN

Gene ID

6498

UniProt

P12757

Tissue Specificity

Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.

Cell Line Specificity

Low cancer specificity

Function

May have regulatory role in cell division or differentiation in response to extracellular signals.

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