Anti-SIRPA Monoclonal Antibody (1H6)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC550	Anti-SIRPA Antibody (1H6)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC550-P	Anti-SIRPA Antibody (1H6), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC550-A	Anti-SIRPA Antibody (1H6), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC550-H	Anti-SIRPA Antibody (1H6), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC550-B	Anti-SIRPA Antibody (1H6), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-SIRPA Monoclonal Antibody (1H6)
- Product Description:
  
  The Anti-SIRPA antibody is a human monoclonal antibody recommended for use in ELISA, inhibition, functional assay and other applications. This antibody specifically targets SIRPA and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Inhibition, Functional Assay, Western Blot
  
  Target:
  
  SIRPA
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human SIRPA.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  1H6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-SIRPA Monoclonal Antibody (1H6) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

SIRPA

Protein Name

Tyrosine-protein phosphatase non-receptor type substrate 1

Introduction

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family.

Alternative Names

SIRPA; signal-regulatory protein alpha; BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1

Gene ID

140885

UniProt

P78324

Molecule Mass

CD Molecules

Subcellular Location

Membrane; Single-pass type I membrane protein.

Cell Line Specificity

Cancer enhanced

Function

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity).

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