Anti-SIGLEC7 Monoclonal Antibody

Subcat	Description	Isotype	Conjugate	Price
ASPC1588	Anti-SIGLEC7 Antibody	Human IgG1, Lambda	None	$530	Add
ASPC1588-A	Anti-SIGLEC7 Antibody, APC	Human IgG1, Lambda	APC	$1,030	Add
ASPC1588-B	Anti-SIGLEC7 Antibody, Biotin	Human IgG1, Lambda	Biotin	$760	Add
ASPC1588-H	Anti-SIGLEC7 Antibody, HRP	Human IgG1, Lambda	HRP	$680	Add
ASPC1588-P	Anti-SIGLEC7 Antibody, PE	Human IgG1, Lambda	PE	$1,280	Add

Anti-SIGLEC7 Monoclonal Antibody
- Product Description:
  
  The Anti-SIGLEC7 antibody is a human monoclonal antibody recommended for enzyme-linked immunosorbent assay, western blot, surface plasmon resonance and other applications. This antibody specifically targets SIGLEC7 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot, Surface Plasmon Resonance
  
  Source:
  
  Human
  
  Target:
  
  SIGLEC7
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human SIGLEC7.
  
  Immunogen:
  
  Human SIGLEC7
  
  Clonality:
  
  Monoclonal
  
  Isotype:
  
  Human IgG1, Lambda
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-SIGLEC7 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

SIGLEC7

Protein Name

Sialic acid-binding Ig-like lectin 7

Introduction

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328 (cluster of differentiation 328). Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Alternative Names

p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1

Gene ID

27036

UniProt

Q9Y286

Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

Cell Line Specificity

Group enriched (Leukemia, Myeloma)

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

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