Anti-SIGLEC7 Monoclonal Antibody (8B11)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC393	Anti-SIGLEC7 Antibody (8B11)	Mouse IgG1, Kappa	None	$460	In stock	Add
ASPC393-P	Anti-SIGLEC7 Antibody (8B11), PE	Mouse IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC393-A	Anti-SIGLEC7 Antibody (8B11), APC	Mouse IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC393-H	Anti-SIGLEC7 Antibody (8B11), HRP	Mouse IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC393-B	Anti-SIGLEC7 Antibody (8B11), Biotin	Mouse IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-SIGLEC7 Monoclonal Antibody (8B11)
- Product Description:
  
  The Anti-SIGLEC7 antibody is a mouse monoclonal antibody recommended for use in western blot, ELISA, flow cytometry, neutralization and other applications. This antibody specifically targets SIGLEC7 and demonstrates reactivity with human.
  
  Applications:
  
  Western Blot, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Neutralization
  
  Target:
  
  SIGLEC7
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human SIGLEC7.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  8B11
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-SIGLEC7 Monoclonal Antibody (8B11) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

SIGLEC7

Protein Name

Sialic acid-binding Ig-like lectin 7

Introduction

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328 (cluster of differentiation 328). Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Alternative Names

p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1

Gene ID

27036

UniProt

Q9Y286

Molecule Mass

CD Molecules, Siglec Molecules

Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

Cell Line Specificity

Group enriched

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

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