Anti-SHH Monoclonal Antibody (1B10)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC360	Anti-SHH Antibody (1B10)	Rabbit IgG, Kappa	None	$460	In stock	Add
ASPC360-P	Anti-SHH Antibody (1B10), PE	Rabbit IgG, Kappa	PE	$1,180	2-3 weeks	Add
ASPC360-A	Anti-SHH Antibody (1B10), APC	Rabbit IgG, Kappa	APC	$980	2-3 weeks	Add
ASPC360-H	Anti-SHH Antibody (1B10), HRP	Rabbit IgG, Kappa	HRP	$600	2-3 weeks	Add
ASPC360-B	Anti-SHH Antibody (1B10), Biotin	Rabbit IgG, Kappa	Biotin	$680	2-3 weeks	Add

Anti-SHH Monoclonal Antibody (1B10)
- Product Description:
  
  The Anti-SHH antibody is a rabbit monoclonal antibody recommended for use in ELISA, western blot and other applications. This antibody specifically targets SHH and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot
  
  Target:
  
  SHH
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Hedgehog.
  
  Immunogen:
  
  Human Sonic Hedgehog
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  1B10
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-SHH Monoclonal Antibody (1B10) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

SHH

Protein Name

Sonic hedgehog protein

Introduction

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Alternative Names

TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5

Gene ID

6469

UniProt

Q15465

Related Disease

Microphthalmia/Coloboma 5 (MCOPCB5)

Subcellular Location

[Sonic hedgehog protein]: Endoplasmic reticulum membrane

Cell Line Specificity

Cancer enhanced