-
Anti-SEMA5A Monoclonal Antibody (C-10A10)
-
Product Description:The Anti-SEMA5A antibody is a mouse monoclonal antibody recommended for western blot and other applications. This antibody specifically targets human and rat SEMA5A.Applications:Western BlotSource:MouseTarget:SEMA5ATarget Species:HumanSpecificity:This antibody reacts with human Semaphorin 5A (SEMA5A).Immunogen:Recombinant SEMA5A proteinClonality:MonoclonalClone ID:C-10A10Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.05% Proclin 300Shipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
-
-
Anti-SEMA5A Monoclonal Antibody (C-10A10) Applications
-
Recommended Dilution:Western Blot: 0.01-2 µg/mLNote:Optimal dilutions/concentrations should be determined by the end user.
-
Protein Name
Semaphorin-5A
Introduction
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.
Alternative Names
SEMAF; semF
Gene ID
UniProt
Subcellular Location
Membrane; Single-pass type I membrane protein.
Cell Line Specificity
Cancer enhanced
Function
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Customer Reviews
There are no reviews for Product Name.
Submit a review and receive an Amazon gift card.
Publications
There are no publications for Product Name.
If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward
