Anti-SEMA4A Monoclonal Antibody (2H5)

Subcat	Description	Isotype	Conjugate	Price
ASPC392	Anti-SEMA4A Antibody (2H5)	Mouse IgG2a, Kappa	None	$460	Add
ASPC392-P	Anti-SEMA4A Antibody (2H5), PE	Mouse IgG2a, Kappa	PE	$1,180	Add
ASPC392-A	Anti-SEMA4A Antibody (2H5), APC	Mouse IgG2a, Kappa	APC	$980	Add
ASPC392-H	Anti-SEMA4A Antibody (2H5), HRP	Mouse IgG2a, Kappa	HRP	$600	Add
ASPC392-B	Anti-SEMA4A Antibody (2H5), Biotin	Mouse IgG2a, Kappa	Biotin	$680	Add

Anti-SEMA4A Monoclonal Antibody (2H5)
- Product Description:
  
  The Anti-SEMA4A antibody is a mouse monoclonal antibody recommended for use in ELISA, flow cytometry, immunohistochemistry, blocking and other applications. This antibody specifically targets SEMA4A and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry, Blocking, Western Blot
  
  Target:
  
  SEMA4A
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human SEMA4A.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  2H5
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-SEMA4A Monoclonal Antibody (2H5) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

SEMA4A

Protein Name

Semaphorin-4A

Introduction

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative Names

SEMA4A; sema domain; immunoglobulin domain (Ig); transmembrane domain (TM) and short cytoplasmic domain; (semaphorin) 4A; RP35; SEMB; SEMAB; CORD10; semaphorin-4A; sema B; semaphorin-B

Gene ID

64218

UniProt

Q9H3S1

Related Disease

Retinitis pigmentosa 35 (RP35)

Subcellular Location

Cell membrane

Cell Line Specificity

Cancer enhanced

Function

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).

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