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Anti-SELP Monoclonal Antibody (4H9)
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Product Description:The Anti-SELP antibody is a mouse monoclonal antibody recommended for use in inhibition, flow cytometry and other applications. This antibody specifically targets SELP and demonstrates reactivity with human.Applications:Inhibition, Flow CytometryTarget:SELPTarget Species:HumanSpecificity:This antibody reacts with human SELP.Clonality:MonoclonalClone ID:4H9Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-SELP Monoclonal Antibody (4H9) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
SELP
Protein Name
P-selectin
Introduction
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented.
Alternative Names
SELP; Selectin P; CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM; P-selectin
Gene ID
UniProt
Molecule Mass
Adhesion Molecules, CD Molecules
Subcellular Location
Cell membrane
Tissue Specificity
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Cell Line Specificity
Cancer enriched
Function
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3).
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