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Anti-RNF43 Monoclonal Antibody (4G5)
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Product Description:The Anti-RNF43 antibody is a mouse monoclonal antibody recommended for use in western blot, ELISA, flow cytometry, immunohistochemistry, immunoprecipitation and other applications. This antibody specifically targets RNF43 and demonstrates reactivity with human.Applications:Western Blot, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry, ImmunoprecipitationTarget:RNF43Target Species:HumanSpecificity:This antibody reacts with human RNF43.Immunogen:Human Ring Finger Protein 43Clonality:MonoclonalClone ID:4G5Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-RNF43 Monoclonal Antibody (4G5) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
RNF43
Protein Name
E3 ubiquitin-protein ligase RNF43
Introduction
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alternative Names
URCC; SSPCS; RNF124
Gene ID
UniProt
Related Disease
Sessile serrated polyposis cancer syndrome (SSPCS)
Tissue Specificity
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
Cell Line Specificity
Cancer enhanced
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity).
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