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Anti-PTPRC Monoclonal Antibody (10A9)
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Product Description:The Anti-PTPRC antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry and other applications. This antibody specifically targets PTPRC and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Flow CytometryTarget:PTPRCTarget Species:HumanSpecificity:This antibody reacts with human PTPRC.Clonality:MonoclonalClone ID:10A9Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-PTPRC Monoclonal Antibody (10A9) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
PTPRC
Protein Name
Receptor-type tyrosine-protein phosphatase C
Introduction
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.
Alternative Names
PTPRC; Receptor-type tyrosine-protein phosphatase C; CD45
Gene ID
UniProt
Molecule Mass
CD Molecules, Protein Kinases/Phosphatase, TCRs
Related Disease
Multiple sclerosis (MS)
Subcellular Location
Cell membrane
Cell Line Specificity
Group enriched
Function
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
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