Anti-PTPRB Monoclonal Antibody (14B5)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC406	Anti-PTPRB Antibody (14B5)	Human IgG4, Kappa		None	$460	4-6 weeks	Add
ASPC406-1	Anti-PTPRB Antibody (14B5), Fab fragment	Human Fab	His tag	None	$460	In stock	Add
ASPC406-2	Anti-PTPRB Antibody (14B5), scFv fragment	Human scFv	His tag	None	$460	In stock	Add
ASPC406-P	Anti-PTPRB Antibody (14B5), PE	Human IgG4, Kappa		PE	$1,180	4-6 weeks	Add
ASPC406-A	Anti-PTPRB Antibody (14B5), APC	Human IgG4, Kappa		APC	$980	4-6 weeks	Add
ASPC406-H	Anti-PTPRB Antibody (14B5), HRP	Human IgG4, Kappa		HRP	$600	4-6 weeks	Add
ASPC406-B	Anti-PTPRB Antibody (14B5), Biotin	Human IgG4, Kappa		Biotin	$680	4-6 weeks	Add

Anti-PTPRB Monoclonal Antibody (14B5)
- Product Description:
  
  The Anti-PTPRB antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry and other applications. This antibody specifically targets PTPRB and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Target:
  
  PTPRB
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human PTPRB.
  
  Immunogen:
  
  Human PTPRB extracellular domain
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  14B5
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-PTPRB Monoclonal Antibody (14B5) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

PTPRB

Protein Name

Receptor-type tyrosine-protein phosphatase beta

Introduction

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene.

Alternative Names

PTPRB; protein tyrosine phosphatase; receptor type; B; PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA

Gene ID

5787

UniProt

P23467

Subcellular Location

Membrane

Cell Line Specificity

Cancer enhanced

Function

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

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