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Anti-PTGER4 Monoclonal Antibody (5F2)
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Product Description:The Anti-PTGER4 antibody is a mouse monoclonal antibody recommended for use in flow cytometry and other applications. This antibody specifically targets PTGER4 and demonstrates reactivity with human.Applications:Flow CytometryTarget:PTGER4Target Species:HumanSpecificity:This antibody reacts with human PTGER4.Immunogen:Human PTGER4 proteinClonality:MonoclonalClone ID:5F2Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-PTGER4 Monoclonal Antibody (5F2) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
PTGER4
Protein Name
Prostaglandin E2 receptor EP4 subtype
Introduction
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
Alternative Names
PTGER4; prostaglandin E receptor 4 (subtype EP4); EP4; EP4R; prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype
Gene ID
UniProt
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Tissue Specificity
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Cell Line Specificity
Low cancer specificity
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
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