Anti-PROC Monoclonal Antibody (HPC-4)

Anti-PROC Monoclonal Antibody (HPC-4)

Cat No: ASPF136

Summary
Host Species:
Mouse
Species Reactivity:
Baboon, Human
Applications:
Blocking, Enzyme-linked Immunosorbent Assay
Clone ID:
HPC-4
Clonality:
Monoclonal

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Product Information
Subcat Description Isotype Antibody Modification Conjugate Size Price Quantity
ASPF136 Anti-PROC Antibody (HPC-4) Mouse IgG1 None $460
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ASPF136-A Anti-PROC Antibody (HPC-4), APC Mouse IgG1 APC $980
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ASPF136-B Anti-PROC Antibody (HPC-4), Biotin Mouse IgG1 Biotin $680
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ASPF136-H Anti-PROC Antibody (HPC-4), HRP Mouse IgG1 HRP $600
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ASPF136-P Anti-PROC Antibody (HPC-4), PE Mouse IgG1 PE $1,180
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Custom Antibody We can also offer conjugation antibodies (Alexa Fluor, Cy, APC, etc.) and other format antibodies (low endotoxin, Fab, scFv, etc.)

  • Anti-PROC Monoclonal Antibody (HPC-4)
    • Product Description:
      This product is a mouse monoclonal antibody (clone HPC-4) that selectively binds the activation peptide of human protein C (EDQVDPRLIDGK) without reacting with activated protein C, is validated in blocking and ELISA, is azide-free, and is employed to quantify protein C zymogen in plasma and to study anticoagulant pathways.
      Applications:
      Blocking, Enzyme-linked Immunosorbent Assay
      Source:
      Mouse
      Target:
      PROC
      Target Species:
      Human
      Specificity:
      This antibody specifically binds to a twelve-peptide sequence (EDQVDPRLIDGK) located in the activation region of protein C, spanning the thrombin cleavage site. It does not react with activated protein C. This antibody is also cross-reactive with baboon protein C but shows no binding to bovine or mouse protein C.
      Immunogen:
      Human protein C.
      Epitope:
      EDQVDPRLIDGK
      Clonality:
      Monoclonal
      Clone ID:
      HPC-4
      Purification:
      The antibody was purified by affinity chromatography.
      Purity:
      >95% as determined by SDS-PAGE
      Aggregation:
      <5% as determined by SEC
      Form:
      Liquid
      Endotoxin:
      Please contact us for more information.
      Formulation:
      Contact us for custom product formulation.
      Preservative:
      BSA and Azide free.
      Stabilizer:
      None
      Shipping:
      Shipped at 4°C.
      Storage:
      This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
  • Anti-PROC Monoclonal Antibody (HPC-4) Applications
    • Note:
      Optimal dilutions/concentrations should be determined by the end user.
Gene Symbol
PROC
Protein Name
Vitamin K-dependent protein C
Introduction
PROC is the gene that encodes Protein C, a vitamin K-dependent serine protease that plays a crucial role in regulating blood coagulation. Activated protein C (APC) degrades clotting factors Va and VIIIa, thus inhibiting the blood clotting cascade and preventing excessive clot formation.
Alternative Names
Autoprothrombin IIA; HPC4; Vitamin K-dependent protein C; Anticoagulant protein C; Blood coagulation factor XIV; PROC
Related Disease
Thrombophilia
Tissue Specificity
Tissue enriched (Liver)
Cell Line Specificity
Cancer enriched (Liver cancer)
Function
Protein C, a vitamin K-dependent protein that functions as a natural anticoagulant.
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