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Anti-PRNP Monoclonal Antibody (VRQ14)
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Product Description:The Anti-PRNP antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, immunoprecipitation and other applications. This antibody specifically targets PRNP and demonstrates reactivity with Sheep.Applications:Enzyme-Linked Immunosorbent Assay, ImmunoprecipitationTarget:PRNPSpecificity:This antibody reacts with PRNP.Clonality:MonoclonalClone ID:VRQ14Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-PRNP Monoclonal Antibody (VRQ14) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
PRNP
Protein Name
Major prion protein
Introduction
Enables several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and cupric ion binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to membrane; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of apoptotic process; regulation of potassium ion transmembrane transport; and response to oxidative stress. Located in several cellular components, including Golgi apparatus; membrane raft; and terminal bouton. Colocalizes with dendrite. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ.
Alternative Names
Major prion protein; PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; Prnp; prP27-30; prP33-35C
Gene ID
UniProt
Subcellular Location
Cell membrane
Function
Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
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