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Anti-Prnp Monoclonal Antibody (6H10)
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Product Description:The Anti-PRNP antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, neutralization, immunoprecipitation and other applications. This antibody specifically targets PRNP and demonstrates reactivity with Bovine, Sheep, Mouse.Applications:Enzyme-Linked Immunosorbent Assay, Neutralization, ImmunoprecipitationTarget:PRNPSpecificity:This antibody reacts with PRNP.Clonality:MonoclonalClone ID:6H10Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-Prnp Monoclonal Antibody (6H10) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
Prnp
Protein Name
Major prion protein
Introduction
Enables several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and cupric ion binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to membrane; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of apoptotic process; regulation of potassium ion transmembrane transport; and response to oxidative stress. Located in several cellular components, including Golgi apparatus; membrane raft; and terminal bouton. Colocalizes with dendrite. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ.
Alternative Names
Major prion protein; PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; Prnp; prP27-30; prP33-35C
Gene ID
UniProt
Subcellular Location
Cell membrane
Tissue Specificity
Highly expressed in the brain, lung, kidney and heart. Expressed at low levels in the liver and spleen.
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