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Anti-PRNP Monoclonal Antibody (4B10)
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Product Description:The Anti-PRNP antibody is a mouse monoclonal antibody recommended for use in ELISA, inhibition, immunofluorescence and other applications. This antibody specifically targets PRNP and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Inhibition, ImmunofluorescenceTarget:PRNPTarget Species:HumanSpecificity:This antibody reacts with human PRNP.Immunogen:Human prion protein (PRNP)Clonality:MonoclonalClone ID:4B10Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-PRNP Monoclonal Antibody (4B10) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
PRNP
Protein Name
Major prion protein
Introduction
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp.
Alternative Names
CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C
Gene ID
UniProt
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor
Cell Line Specificity
Low cancer specificity
Function
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
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