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Anti-PLAUR Monoclonal Antibody (14A9)
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Product Description:The Anti-PLAUR antibody is a mouse monoclonal antibody recommended for use in western blot, ELISA, functional assay and other applications. This antibody specifically targets PLAUR and demonstrates reactivity with human.Applications:Western Blot, Enzyme-Linked Immunosorbent Assay, Functional AssayTarget:PLAURTarget Species:HumanSpecificity:This antibody reacts with human PLAUR.Immunogen:Human PLAUR proteinClonality:MonoclonalClone ID:14A9Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-PLAUR Monoclonal Antibody (14A9) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
PLAUR
Protein Name
Urokinase plasminogen activator surface receptor
Introduction
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Alternative Names
PLAUR; plasminogen activator; urokinase receptor; CD87; UPAR; URKR; U-PAR; urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; urokinase-type plasminogen activator (uPA) receptor
Gene ID
UniProt
Molecule Mass
CD Molecules
Subcellular Location
Cell membrane
Tissue Specificity
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Cell Line Specificity
Low cancer specificity
Function
Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
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