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Anti-PDCD1 Monoclonal Antibody (hPD-1)
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Product Description:The Anti-PDCD1 antibody is a mouse monoclonal antibody recommended for enzyme-linked immunosorbent assay, inhibition and other applications. This antibody specifically targets the extracellular region of the human PD-1. The antibody can block the interaction between PD-1 and its ligands.Applications:Enzyme-Linked Immunosorbent Assay, InhibitionSource:MouseTarget:PDCD1Target Species:HumanSpecificity:This antibody reacts with human PDCD1.Immunogen:Human PD-1.Affinity Constant:The affinity constant is 23 pM.Clonality:MonoclonalClone ID:hPD-1Isotype:Mouse IgG1, KappaPurification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.Form:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:Azide freeStabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-PDCD1 Monoclonal Antibody (hPD-1) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
PDCD1
Protein Name
Programmed cell death protein 1
Introduction
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
Alternative Names
PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; AIMTBS
Gene ID
UniProt
Related Disease
Systemic lupus erythematosus 2 (SLEB2)
Subcellular Location
Cell membrane
Cell Line Specificity
Cancer enhanced (Breast cancer, Lymphoma)
Function
Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).
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