Anti-PDCD1 Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Conjugate	Price
ASPC1569	Anti-PDCD1 Antibody	Human IgG1, Kappa	None	$530	Add
ASPC1569-A	Anti-PDCD1 Antibody, APC	Human IgG1, Kappa	APC	$1,030	Add
ASPC1569-B	Anti-PDCD1 Antibody, Biotin	Human IgG1, Kappa	Biotin	$760	Add
ASPC1569-H	Anti-PDCD1 Antibody, HRP	Human IgG1, Kappa	HRP	$680	Add
ASPC1569-P	Anti-PDCD1 Antibody, PE	Human IgG1, Kappa	PE	$1,280	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1569

Anti-PDCD1 Antibody

Human IgG1, Kappa

None

$530

Add

ASPC1569-A

Anti-PDCD1 Antibody, APC

Human IgG1, Kappa

APC

$1,030

Add

ASPC1569-B

Anti-PDCD1 Antibody, Biotin

Human IgG1, Kappa

Biotin

$760

Add

ASPC1569-H

Anti-PDCD1 Antibody, HRP

Human IgG1, Kappa

HRP

$680

Add

ASPC1569-P

Anti-PDCD1 Antibody, PE

Human IgG1, Kappa

$1,280

Add

Anti-PDCD1 Monoclonal Antibody
- Product Description:
  
  The Anti-PDCD1 antibody is a human monoclonal antibody recommended for enzyme-linked immunosorbent assay, surface plasmon resonance, inhibition, blocking and other applications. The antibody is designed to specifically bind to the PD-1 protein (Programmed Death-1). By binding to PD-1, the antibody blocks its interaction with its ligands, PD-L1 and/or PD-L2.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Surface Plasmon Resonance, Inhibition, Blocking
  
  Target:
  
  PDCD1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human PDCD1.
  
  Immunogen:
  
  Human PD-1-mFc protein.
  
  Affinity Constant:
  
  The affinity constant is 0.807 nM.
  
  Clonality:
  
  Monoclonal
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-PDCD1 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

PDCD1

Protein Name

Programmed cell death protein 1

Introduction

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; AIMTBS

Gene ID

5133

UniProt

Q15116

Related Disease

Systemic lupus erythematosus 2 (SLEB2)

Subcellular Location

Cell membrane

Cell Line Specificity

Cancer enhanced (Breast cancer, Lymphoma)

Function

Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).

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