Anti-PDCD1 Monoclonal Antibody (13G8)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC287	Anti-PDCD1 Antibody (13G8)	Human IgG1, Lambda	None	$460	In stock	Add
ASPC287-P	Anti-PDCD1 Antibody (13G8), PE	Human IgG1, Lambda	PE	$1,180	2-3 weeks	Add
ASPC287-A	Anti-PDCD1 Antibody (13G8), APC	Human IgG1, Lambda	APC	$980	2-3 weeks	Add
ASPC287-H	Anti-PDCD1 Antibody (13G8), HRP	Human IgG1, Lambda	HRP	$600	2-3 weeks	Add
ASPC287-B	Anti-PDCD1 Antibody (13G8), Biotin	Human IgG1, Lambda	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC287

Anti-PDCD1 Antibody (13G8)

Human IgG1, Lambda

None

$460

In stock

Add

ASPC287-P

Anti-PDCD1 Antibody (13G8), PE

Human IgG1, Lambda

$1,180

2-3 weeks

Add

ASPC287-A

Anti-PDCD1 Antibody (13G8), APC

Human IgG1, Lambda

APC

$980

2-3 weeks

Add

ASPC287-H

Anti-PDCD1 Antibody (13G8), HRP

Human IgG1, Lambda

HRP

$600

2-3 weeks

Add

ASPC287-B

Anti-PDCD1 Antibody (13G8), Biotin

Human IgG1, Lambda

Biotin

$680

2-3 weeks

Add

Anti-PDCD1 Monoclonal Antibody (13G8)
- Product Description:
  
  The Anti-PDCD1 antibody is a human monoclonal antibody recommended for use in ELISA, functional assay and other applications. This antibody specifically targets PDCD1 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Functional Assay
  
  Target:
  
  PDCD1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human PD-1 (Programmed death 1).
  
  Immunogen:
  
  Recombinant Human PDCD1 fusion protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  13G8
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-PDCD1 Monoclonal Antibody (13G8) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

PDCD1

Protein Name

Programmed cell death protein 1

Introduction

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; AIMTBS

Gene ID

5133

UniProt

Q15116

Molecule Mass

CD Molecules, Immune Checkpoint Receptors

Related Disease

Systemic lupus erythematosus 2 (SLEB2)

Subcellular Location

Cell membrane

Cell Line Specificity

Cancer enhanced

Function

Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).

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