Anti-PCSK9 Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Conjugate	Price
ASPC1306	Anti-PCSK9 Antibody	Human IgG1, Kappa	None	$460	Add
ASPC1306-A	Anti-PCSK9 Antibody, APC	Human IgG1, Kappa	APC	$980	Add
ASPC1306-B	Anti-PCSK9 Antibody, Biotin	Human IgG1, Kappa	Biotin	$680	Add
ASPC1306-H	Anti-PCSK9 Antibody, HRP	Human IgG1, Kappa	HRP	$600	Add
ASPC1306-P	Anti-PCSK9 Antibody, PE	Human IgG1, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1306

Anti-PCSK9 Antibody

Human IgG1, Kappa

None

$460

Add

ASPC1306-A

Anti-PCSK9 Antibody, APC

Human IgG1, Kappa

APC

$980

Add

ASPC1306-B

Anti-PCSK9 Antibody, Biotin

Human IgG1, Kappa

Biotin

$680

Add

ASPC1306-H

Anti-PCSK9 Antibody, HRP

Human IgG1, Kappa

HRP

$600

Add

ASPC1306-P

Anti-PCSK9 Antibody, PE

Human IgG1, Kappa

$1,180

Add

Anti-PCSK9 Monoclonal Antibody
- Product Description:
  
  The Anti-PCSK9 antibody is a human monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, blocking, western blot, functional assay and other applications. This antibody specifically targets PCSK9 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Blocking, Western Blot, Functional Assay
  
  Source:
  
  Human
  
  Target:
  
  PCSK9
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human PCSK9.
  
  Immunogen:
  
  Recombinant human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9).
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-PCSK9 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

PCSK9

Protein Name

Proprotein convertase subtilisin/kexin type 9

Introduction

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

Alternative Names

FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9

Gene ID

255738

UniProt

Q8NBP7

Subcellular Location

Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus.

Tissue Specificity

Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

Cell Line Specificity

Low cancer specificity

Function

Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments.

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