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Anti-PAK4 Monoclonal Antibody (G-7B2)
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Product Description:The Anti-PAK4 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human PAK4.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:PAK4Target Species:HumanSpecificity:This antibody reacts with human P21 (RAC1) Activated Kinase 4 (PAK4).Clonality:MonoclonalClone ID:G-7B2Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.02% sodium azideShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-PAK4 Monoclonal Antibody (G-7B2) Applications
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Recommended Dilution:Western Blot: 1:500-1:5000
Immunohistochemistry: 1:50-1:200
Immunocytochemistry: 1:50-1:200Note:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Serine/threonine-protein kinase PAK 4
Introduction
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alternative Names
P21 (RAC1) Activated Kinase 4; EC 2.7.11.1; P21 Protein (Cdc42/Rac)-Activated Kinase 4; P21(CDKN1A)-Activated Kinase 4; P21-Activated Kinase 4; EC 2.7.11; KIAA1142; PAK-4
Gene ID
UniProt
Subcellular Location
Cytoplasm
Tissue Specificity
Highest expression in prostate, testis and colon.
Cell Line Specificity
Low cancer specificity
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