Anti-PADI4 Monoclonal Detection Antibody

Subcat	Description	Isotype	Conjugate	Price
ASPR64	Anti-PADI4 Detection Antibody	Mouse IgG1, Kappa	None	$530	Add
ASPR64-A	Anti-PADI4 Detection Antibody, APC	Mouse IgG1, Kappa	APC	$1,030	Add
ASPR64-B	Anti-PADI4 Detection Antibody, Biotin	Mouse IgG1, Kappa	Biotin	$760	Add
ASPR64-H	Anti-PADI4 Detection Antibody, HRP	Mouse IgG1, Kappa	HRP	$680	Add
ASPR64-P	Anti-PADI4 Detection Antibody, PE	Mouse IgG1, Kappa	PE	$1,280	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPR64

Anti-PADI4 Detection Antibody

Mouse IgG1, Kappa

None

$530

Add

ASPR64-A

Anti-PADI4 Detection Antibody, APC

Mouse IgG1, Kappa

APC

$1,030

Add

ASPR64-B

Anti-PADI4 Detection Antibody, Biotin

Mouse IgG1, Kappa

Biotin

$760

Add

ASPR64-H

Anti-PADI4 Detection Antibody, HRP

Mouse IgG1, Kappa

HRP

$680

Add

ASPR64-P

Anti-PADI4 Detection Antibody, PE

Mouse IgG1, Kappa

$1,280

Add

Anti-PADI4 Monoclonal Detection Antibody
- Product Description:
  
  The anti-PADI4 antibody is a mouse monoclonal antibody recommended for Western Blot, Enzyme-Linked Immunosorbent Assay. This antibody specifically targets PADI4 and demonstrates reactivity with human.
  
  Applications:
  
  Western Blot, Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  PADI4
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human PADI4.
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-PADI4 Monoclonal Detection Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

PADI4

Protein Name

Protein-Arginine Deiminase Type-4

Introduction

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at Arg-54 (to form H1R54ci), histone H3 at Arg-2, Arg-8, Arg-17 and/or Arg-26 (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at Arg-3 (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of Arg-54 of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at Arg-2142, which favors its interaction with NCOA2/GRIP1.

Alternative Names

PADI4; PDI4; Peptidylarginine Deiminase IV; EC 3.5.3.15; PADI5; Protein-Arginine Deiminase Type IV; PAD; Peptidyl Arginine Deiminase, Type V; Peptidyl Arginine Deiminase, Type IV; PAD4; PADI-H Protein

Gene ID

23569

UniProt

Q9UM07

Related Disease

Rheumatoid arthritis (RA)

Subcellular Location

Cytoplasm
Nucleus

Tissue Specificity

Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes.

Function

Chromatin regulator
Hydrolase