Anti-OLR1 Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Conjugate	Price
ASPC1562	Anti-OLR1 Antibody	Human IgG1, Kappa	None	$530	Add
ASPC1562-A	Anti-OLR1 Antibody, APC	Human IgG1, Kappa	APC	$1,030	Add
ASPC1562-B	Anti-OLR1 Antibody, Biotin	Human IgG1, Kappa	Biotin	$760	Add
ASPC1562-H	Anti-OLR1 Antibody, HRP	Human IgG1, Kappa	HRP	$680	Add
ASPC1562-P	Anti-OLR1 Antibody, PE	Human IgG1, Kappa	PE	$1,280	Add

Anti-OLR1 Monoclonal Antibody
- Product Description:
  
  The Anti-OLR1 antibody is a human monoclonal antibody recommended for enzyme-linked immunosorbent assay and other applications. This antibody specifically targets OLR1 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  OLR1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human OLR1.
  
  Immunogen:
  
  Human OLR1
  
  Clonality:
  
  Monoclonal
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-OLR1 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

OLR1

Protein Name

Oxidized low-density lipoprotein receptor 1

Introduction

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.

Alternative Names

CLEC8A; LOX1; LOXIN; SCARE1; SLOX1

Gene ID

4973

UniProt

P78380

Tissue Specificity

Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.

Cell Line Specificity

Cancer enhanced (Cervical cancer, Head and neck cancer)

Function

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

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