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Anti-NRP1 Monoclonal Antibody (7H5)
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Product Description:The Anti-NRP1 antibody is a rabbit monoclonal antibody recommended for use in immunohistochemistry and other applications. This antibody specifically targets NRP1 and demonstrates reactivity with human.Applications:ImmunohistochemistryTarget:NRP1Target Species:HumanSpecificity:This antibody reacts with human NRP1.Immunogen:Human Neuropilin 1Clonality:MonoclonalClone ID:7H5Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-NRP1 Monoclonal Antibody (7H5) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
NRP1
Protein Name
Neuropilin-1
Introduction
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Alternative Names
NRP1; neuropilin 1; NP1; NRP; BDCA4; CD304; VEGF165R; neuropilin-1
Gene ID
UniProt
Molecule Mass
Adhesion Molecules, CD Molecules
Subcellular Location
[Isoform 2]: Secreted
Cell Line Specificity
Low cancer specificity
Function
Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins.
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