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Anti-NPR1 Monoclonal Antibody (9A10)
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Product Description:The Anti-NPR1 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry, functional assay and other applications. This antibody specifically targets NPR1 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Functional AssayTarget:NPR1Target Species:HumanSpecificity:This antibody reacts with human NPRA (Natriuretic peptide receptor A).Clonality:MonoclonalClone ID:9A10Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-NPR1 Monoclonal Antibody (9A10) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
NPR1
Protein Name
Atrial natriuretic peptide receptor 1
Introduction
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).
Alternative Names
ANPa; NPRA; ANPRA; GUC2A; GUCY2A
Gene ID
UniProt
Subcellular Location
Membrane; Single-pass type I membrane protein.
Cell Line Specificity
Cancer enhanced
Function
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
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